Quick Details Payment Terms: L/C,D/A,D/P,T/T,Western Union,MoneyGram SHELF LIFE: 2years Sample: Availiable Product Name: Marbofloxacin MW: 637.66 Grade: Phamaceutical Grade Dosage Form: Powder odor: characteristic Density: 268-269°C Appearance: white powder Assay: 98% Function: Parasite Drugs Animal Type: cattle,fowl,Horse,PETS,PIG,SHEEP Packaging Detail: 25kg/drum,1kg/bag or according to customer request Product Description Product Description Marbofloxacin is a new type of fluoroquinolone antibiotic, by inhibiting bacterial DNA transcription to inhibit the growth of bacteria, it also has antibacterial activity to the gram-negative bacteria, gram positive bacteria and mycoplasma. Marbofloxacin can be absorbed by oral and injected drugs, and has low toxic and side effect. 1. Pharmacodynamics: wide antimicrobial spectrum, strong antibacterial activity. the MIC90 of most enterobacteriaceae, multiple kill Pasteur's bacteria, pseudomonas aeruginosa, golden yellow staphylococcus and staphylococcus aureus were 0.08 ~ 0.28, 0.04, 0.94, 0.2, and 0.23 mu g/mL, fairly to ciprofloxacin and enrofloxacin. The MIC90 of bovine respiratory pathogens such as kill more sexual Pasteur's bacteria, hemolytic Pasteur's bacteria, lethargy haemophilus and mycoplasma were 0.02, 0.02, 0.03 and 0.48 mu g/mL. The product is still valid to some drug-resistant pathogenic bacteria such as erythromycin, clindamycin, chloramphenicol, doxycycline, sulphonamide pathogen. 2. Pharmacokinetic: absorbed quickly and completely after injection and oral, combining with plasma proteins in low rate, wide distribution in the tissue, distribution in the kidney, liver, lungs and skin is good, its concentration in plasma and tissue is higher than most pathogens’ MIC. The oral bioavailability of pregnant sows and cat is about 80%, calf is above 100%. This product has a large distribution volume (more than 1.3 L/kg), except the central nervous, the drug concentrations of all tested tissue are higher than plasma. Part in hepatic is metabolism into inactive metabolites (N – methyl MBF and N – oxygen MBF). Main excretion way is through kidney, there is about 30%–45% drug prototype in dogs’ urine. Half-life is long, for dogs’ oral and subcutaneous injection, it can be 14 hours and 13hours, for calves (intramuscular injection), chicken (intramuscular injection), the sow (oral), cat (oral), it can be 4.33, 5.26, 5.74 and 10 h. So the effective blood drug concentration can maintain for a long time after doseing. Certification of Analysis Items Specification Appearance White powder Identification Should comply with the RS IR absorption spectrum Absorbance ≤0.20 Impurity A ≤0.1% Impurity B ≤0.1% Impurity C ≤0.2% Impurity D ≤0.2% Impurity E ≤0.2% Unspecified impurities ≤0.2% Total impurities ≤0.5% Heavy metals ≤20 ppm Loss on drying ≤0.5% Sulfated ash ≤0.1% Assay (Dried substance) 99.0~101.0%% Ethanol ≤5000 ppm Dichloromethane ≤600 ppm Standard EP 7.0 Function&Application Marbofloxacin […]
