CAS 59865-13-3 Pharmaceutical Grade 99% Cyclosporin A

Quick Details Port: shanghai Payment Terms: L/C,D/A,D/P,T/T,Western Union,MoneyGram Supply Ability: 3000.0 Kilogram/Kilograms per Month Other Names: Cyclosporin A Usage: Animal Pharmaceuticals Grade Standard: Medicine Grade Purity: 99% Shelf life: 2 Years Appearance: White Powder MOQ: 500g/tin CAS No.: 59865-13-3 Type: Vitamins, Amino Acids and Coenzymes EINECS No.: / MF: 62H111N11O12 Packaging Detail: 500g/tin CAS 59865-13-3 Pharmaceutical Grade 99% Cyclosporin A Name: Cyclosporin A Synonym: cyclosporine; Ciclosporin; Cyclosporine A; Cyclosporin; Sandimmune; Cas No: 59865-13-3 MF: C62H111N11O12 Molecular:1202.61 Purity:99% Appearance: white powder Function Cyclosporine is thought to bind to the cytosolic protein cyclophilin(immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes. This complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor NF-AT (nuclear factor of activated T-cells), which moves to the nucleus of the T-cell and increases the activity of genes coding for IL-2 and related cytokines. Ciclosporin prevents the dephosphorlyation of NF-AT by binding to cyclophilin.[7] It also inhibits lymphokine production andinterleukin release and, therefore, leads to a reduced function of effector T-cells. It does not affect cytostaticactivity.   It also […]